The Overcoming COVID-19 study seeks to track and characterize the development of complications in children and young adults as a result of exposure to the novel coronavirus, SARS-CoV-2, one such outcome being Multisystem Inflammatory Syndrome in Children (MIS-C). Through real-time surveillance and reporting, as well as prospective enrollment of study participants with collection of blood and respiratory samples, this study intends to understand the risk factors and outcomes of COVID-19 critical illness in the pediatric population, define complications in young individuals thought to be related to SARS-CoV-2, identify predictive markers of these complications, and characterize the development and maintenance of adaptive immunity.

Who We Are
The Overcoming COVID-19 study team represents a collaboration between over 70 pediatric hospitals nationwide and the Centers for Disease Control and Prevention
About Us
Our Research
We are performing a real-time surveillance of COVID-19 cases in children and analysis of blood and respiratory samples to determine biomarkers of disease susceptibility
Our Research
Our Findings
We are continually reporting and publishing our results to help inform parents, clinicians, and the media about cases, treatments, and diagnostic guidelines of COVID-19
News and Publications
Recent News and Publications
- Covid Hospitalizations in Children Surge to a Record – Bloomberg
- Pfizer-BioNTech’s vaccine is highly effective against hospitalization for those 12 to 18, a study shows – New York Times
- Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents – New England Journal of Medicine
- Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes - New England Journal of Medicine (6/16/2021)
- Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome - JAMA Neurology (3/5/2021)
- Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19 - Journal of the American Medical Association (2/24/2021)
- Multisystem Inflammatory Syndrome in U.S. Children and Adolescents - New England Journal of Medcine (6/29/2020) See all News and Publications